| Identification | Back Directory | [Name]
Tellimagrandin II | [CAS]
81571-72-4 | [Synonyms]
Aids070905
Aids-070905
Tellimagrandin 2
Tellimagrandin II
1-O,2-O,3-O-Trigalloyl-4-O,6-O-(2,2',3,3',4,4'-hexahydroxy[1,1'-biphenyl]-6,6'-diylbiscarbonyl)-β-D-glucopyranose
1-O,2-O,3-O-Trigalloyl-4-O,6-O-[2,2',3,3',4,4'-hexahydroxy[1,1'-biphenyl]-6,6'-diylbis(carbonyl)]-β-D-glucopyranose
4-O,6-O-[(4,4',5,5',6,6'-Hexahydroxy-1,1'-biphenyl-2,2'-diyl)bis(carbonyl)]-1-O,2-O,3-O-trigalloyl-β-D-glucopyranose
β-D-Glucopyranose, cyclic 4,6-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1,2,3-tris(3,4,5-trihydroxybenzoate)
.beta.-D-Glucopyranose, cyclic 4,6-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1,2,3-tris(3,4,5-trihydroxybenzoate) | [Molecular Formula]
C41H30O26 | [MDL Number]
MFCD04113041 | [MOL File]
81571-72-4.mol | [Molecular Weight]
938.66 |
| Chemical Properties | Back Directory | [Boiling point ]
1503.7±65.0 °C(Predicted) | [density ]
2.13±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [form ]
Solid | [pka]
7.50±0.70(Predicted) | [color ]
Off-white to light yellow | [LogP]
3.138 (est) |
| Hazard Information | Back Directory | [Uses]
Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases[1][2][3][4]. | [Biological Activity]
Tellimagrandin II (Eugeniin), the first intermediate in the 4C1-glucose derived series of ellagitannins, also inhibits antibiotic resistance of drug-resistant Staphylococcus aureus[1][2]. | [in vivo]
Tellimagrandin II (100 and 200 mg/kg, p.o., once daily for 10 days) improved learning and memory functions in Scopolamine (HY-N0296)-induced amnesiac ICR mice[4]. | Animal Model: | Scopolamine (HY-N0296)-induced amnesiac ICR mouse model[4] | | Dosage: | 100 and 200 mg/kg | | Administration: | Oral gavage (p.o.), once daily for 10 days | | Result: | Improved learning and memory functions in the passive avoidance and water maze tests. |
| [References]
[1]. Ruth Niemetz, et al. Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves. Phytochemistry. 2003 Feb;62(3):301-6. [2]. Yu-Wei Chang, et al. Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus. Int J Mol Sci. 2019 Nov 18;20(22):5790. |
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