| Identification | Back Directory | [Name]
(R)-(+)-SKF-38393 hydrochloride | [CAS]
81702-42-3 | [Synonyms]
R-SKF-38393A HCl
R(+)-SKF-38393 HYDROCHLORIDE
RSKF38393A HCl,R SKF 38393A HCl | [Molecular Formula]
C16H17NO2.ClH | [MDL Number]
MFCD00055189 | [MOL File]
81702-42-3.mol | [Molecular Weight]
291.776 |
| Chemical Properties | Back Directory | [Melting point ]
244-246 °C | [storage temp. ]
-20°C | [solubility ]
0.1 M HCl: soluble1.2mg/mL | [form ]
solid | [color ]
off-white to light tan | [Optical Rotation]
[α]22/D +16.1°, c = 1.2 in methanol(lit.) | [Water Solubility ]
water: 100mM | [InChI]
1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1 | [InChIKey]
YEWHJCLOUYPAOH-PFEQFJNWSA-N | [SMILES]
Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O |
| Hazard Information | Back Directory | [Uses]
(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). | [Uses]
(R)-(+)-SKF-38393 Hydrochloride is the active enantiomer of (±)-SKF-38393, a D1 dopamine receptor agonist. | [Biochem/physiol Actions]
(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a?benzazepine derivative, exhibits anorectic effects. |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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