| Identification | Back Directory | [Name]
STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem | [CAS]
823828-18-8 | [Synonyms]
C188
Cpd188
Cpd-188
STAT3-IN-C188
STAT3 inhibitor C188
C188 (Synonyms: CPD188)
STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem
Benzoic acid, 4-[[[3-[(carboxymethyl)thio]-4-hydroxy-1-naphthalenyl]amino]sulfonyl]- | [Molecular Formula]
C19H15NO7S2 | [MDL Number]
MFCD05804524 | [MOL File]
823828-18-8.mol | [Molecular Weight]
433.45 |
| Chemical Properties | Back Directory | [Boiling point ]
718.2±70.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL | [form ]
Solid | [pka]
2.40±0.30(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C19H15NO7S2/c21-17(22)10-28-16-9-15(13-3-1-2-4-14(13)18(16)23)20-29(26,27)12-7-5-11(6-8-12)19(24)25/h1-9,20,23H,10H2,(H,21,22)(H,24,25) | [InChIKey]
CIERPRDYPKVDJO-UHFFFAOYSA-N | [SMILES]
[S](=O)(=O)(Nc2c3c(c(c(c2)SCC(=O)O)O)cccc3)c1ccc(cc1)C(=O)O |
| Hazard Information | Back Directory | [Uses]
C188 is a STAT3 inhibitor that inhibits IL-6-stimulated STAT3 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket. C188, in particular, was highly active in inducing apoptosis of the breast cancer cell line MB-MDA-468 in vitro (EC50= 0.7 μM). | [References]
[1] Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS One. 2009;4(3):e4783. DOI:10.1371/journal.pone.0004783 |
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| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|