| Identification | Back Directory | [Name]
2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide | [CAS]
824960-50-1 | [Synonyms]
WDR5-0102
2-chloro-N-(2-(4-methylpiperazin-1-yl)-5-nitrophenyl)benzamide
Benzamide, 2-chloro-N-[2-(4-methyl-1-piperazinyl)-5-nitrophenyl]- | [Molecular Formula]
C18H19ClN4O3 | [MDL Number]
MFCD06622672 | [MOL File]
824960-50-1.mol | [Molecular Weight]
374.82 |
| Chemical Properties | Back Directory | [Boiling point ]
474.4±45.0 °C(Predicted) | [density ]
1.360±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.67±0.70(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5[1][2]. | [References]
[1] Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645. DOI:10.1016/j.bmcl.2018.12.035
[2] Chen X, et al. Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective. J Med Chem. 2021 Aug 12;64(15):10537-10556. DOI:10.1021/acs.jmedchem.1c00037 |
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