| Identification | Back Directory | [Name]
FEN1-IN-1 | [CAS]
824983-91-7 | [Synonyms]
LNT 1
FEN1-IN-1
EN1 Inhibitor C1
FEN1 inhibitor 1
LNT 1 (FEN1-IN-1)
FEN1 IN 1,FEN-1-IN-1,inhibit,Inhibitor,FEN1IN1
1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-
1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione | [Molecular Formula]
C15H12N2O5S | [MOL File]
824983-91-7.mol | [Molecular Weight]
332.33 |
| Chemical Properties | Back Directory | [Boiling point ]
548.9±52.0 °C(Predicted) | [density ]
1.583±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
Soluble in DMSO (15 mg/ml) | [form ]
solid | [pka]
7.91±0.20(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
LNT 1 (824983-91-7) is a potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO1).2 Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.4 | [storage]
Store at -20°C | [References]
Tumey et al. (2005), The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors; Med. Chem. Lett., 15 277
Exell et al. (2016), Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site; Chem. Biol., 12 815
Ward et al. (2017), Small molecules inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes; PLoS One, 12 e0179278
Guo et al. (2020), FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination; Natl. Acad. Sci USA 117 19415 |
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