| Identification | Back Directory | [Name]
Acetamide, N-[3'-[(3,4-dihydro-3-hydroxy-2,4-dioxothieno[3,2-d]pyrimidin-1(2H)-yl)methyl][1,1'-biphenyl]-3-yl]- | [CAS]
824983-93-9 | [Synonyms]
FEN1-IN-5
Acetamide, N-[3'-[(3,4-dihydro-3-hydroxy-2,4-dioxothieno[3,2-d]pyrimidin-1(2H)-yl)methyl][1,1'-biphenyl]-3-yl]- | [Molecular Formula]
C21H17N3O4S | [MOL File]
824983-93-9.mol | [Molecular Weight]
407.44 |
| Hazard Information | Back Directory | [Uses]
FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=12 nM), involving in DNA repair[1]. | [References]
[1] Wadhwa P, et al. QSAR and Docking Studies of N-hydroxy Urea Derivatives as Flap Endonuclease-1 Inhibitors. Curr Comput Aided Drug Des. 2015;11(4):346-52. DOI:10.2174/1573409912666151124233628 |
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