| Identification | Back Directory | [Name]
FEN1-IN-C20 | [CAS]
824983-94-0 | [Synonyms]
FEN1-IN-2
FEN1-IN-C20
[1,1'-Biphenyl]-4-carboxamide, 3'-[(3,4-dihydro-3-hydroxy-2,4-dioxothieno[3,2-d]pyrimidin-1(2H)-yl)methyl]- | [Molecular Formula]
C20H15N3O4S | [MOL File]
824983-94-0.mol | [Molecular Weight]
393.42 |
| Chemical Properties | Back Directory | [Boiling point ]
678.5±65.0 °C(Predicted) | [density ]
1.512±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.85±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
FEN1-IN-2 (compound 20) is a flap endonuclease 1 (FEN1) inhibitor, with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively[1]. | [References]
[1] L Nathan Tumey, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81. DOI:10.1016/j.bmcl.2004.10.086 |
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