| Chemical Properties | Back Directory | [Melting point ]
47-48 °C | [Boiling point ]
294.7±8.0 °C(Predicted) | [density ]
1.01±0.1 g/cm3(Predicted) | [pka]
14.75±0.60(Predicted) | [LogP]
4.250 (est) |
| Hazard Information | Back Directory | [Description]
Lemnalol is a natural marine compound isolated from the Formosan soft coral Lemnalia cervicorni. Lemnalol produced anti-inflammatory and analgesic effects in carrageenan-injected rats. | [Uses]
Lemnalol is a potent agent for neuropathic pain. Lemnalol possesses potent anti-inflammatory, analgesic and anti-tumor activities. Lemnalol has the capacity to attenuate hyperalgesia and allodynia by modulation of neuroinflammatory processes in neuropathy. Lemnalol modulates LPS-induced alterations of left atrial (LA) calcium homeostasis and blocks the NF-κB pathways, which may contribute to the attenuation of lipopolysaccharide (LPS)-induced arrhythmogenesis and neuropathic pain. Lemnalolis a ylangene-type sesquiterpenoid compound, isolated from Lemnalia cervicorni[1][2]. | [References]
[1] Tai BY, et al. Lemnalol Modulates the Electrophysiological Characteristics and Calcium Homeostasis of Atrial Myocytes. Mar Drugs. 2019 Oct 30;17(11):619. DOI:10.3390/md17110619
[2] Lin YC, et al. Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats. Behav Pharmacol. 2011 Dec;22(8):739-50. DOI:10.1097/FBP.0b013e32834d0ecb |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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