| Identification | Back Directory | [Name]
ABZ-GLY-ILE-VAL-ARG-ALA-LYS(DNP)-OH | [CAS]
827044-38-2 | [Synonyms]
ABZ-GLY-ILE-VAL-ARG-ALA-LYS(DNP)-OH
L-Lysine, N-(2-aminobenzoyl)glycyl-L-isoleucyl-L-valyl-L-arginyl-L-alanyl-N6-(2,4-dinitrophenyl)- (9CI) | [Molecular Formula]
C41H61N13O12 | [MDL Number]
MFCD08702753 | [MOL File]
827044-38-2.mol | [Molecular Weight]
928 |
| Hazard Information | Back Directory | [Uses]
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal[1]. | [References]
[1] Cotrin SS, et, al. Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B. Anal Biochem. 2004 Dec 15;335(2):244-52. DOI:10.1016/j.ab.2004.09.012 |
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