| Chemical Properties | Back Directory | [Boiling point ]
539.2±50.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 1 mg/ml | [pka]
4.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
5-cis Iloprost is the C-5 cis-isomer of iloprost, a second generation structural analog of prostaglandin I2 (prostacyclin). Iloprost displays ten-fold greater potency than the first generation stable prostacyclin analogs, typified by carbaprostacyclin.1 There are no published studies of the pharmacological properties of 5-cis iloprost. | [Uses]
(Z)-Iloprost ((Z)-Ciloprost; (Z)-ZK 36374) is a vasodilator that prevents heparin-induced platelet activation[1][2][3]. | [References]
1. Schr?r, K., Darius, H., Matzky, R., et al. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK36374) — equipotent to PGI2 in vitro Naunyn Schmiedebergs Arch. Pharmacol. 316(3),252-255(1981). |
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