| Identification | Back Directory | [Name]
Adenosine 5′-(trihydrogen diphosphate), 2-chloro-, trisodium salt | [CAS]
82927-78-4 | [Synonyms]
2-Chloroadenosine-5'-O-diphosphate sodium
2-Chloroadenosine-5'-O-diphosphate (sodium salt)
Adenosine 5′-(trihydrogen diphosphate), 2-chloro-, trisodium salt | [Molecular Formula]
C10H14ClN5O10P2.3Na | [Molecular Weight]
530.62 |
| Hazard Information | Back Directory | [Uses]
2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sodium is a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase[1]. 2-Chloro-ADP sodium inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM[2]. | [References]
[1] N J Cusack, et al. Competitive inhibition by adenosine 5'-triphosphate of the actions on human platelets of 2-chloroadenosine 5'-diphosphate, 2-azidoadenosine 5'-diphosphate and 2-methylthioadenosine 5'-diphosphate. Br J Pharmacol. 1982 Oct;77(2):329-33. DOI:10.1111/j.1476-5381.1982.tb09302.x
[2] Mitchell A Moseng, et al. 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. FEBS Lett. 2019 Aug;593(15):2030-2039. DOI:10.1002/1873-3468.13475 |
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