| Identification | Back Directory | [Name]
AF 698 | [CAS]
82958-11-0 | [Synonyms]
AF 698
(3α,16α)-Eburnamenine-14-carboxylic acid 1,3-dihydro-3-oxoisobenzofuran-1-yl ester
Eburnamenine-14-carboxylic acid, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, (3α,16α)- (9CI) | [Molecular Formula]
C28H26N2O4 | [MOL File]
82958-11-0.mol | [Molecular Weight]
454.52 |
| Hazard Information | Back Directory | [Description]
AF 698 is a peripheral vasodilator. AF 698 may have a protective effect against the lethalality of hypobaric hypoxia. | [Uses]
AF 698 is a phthalate derivative of Apovincamine (HY-135743) that can be used as a peripheral vasodilator with selective vasomotor effects on cerebral microvascular circulation. AF 698 has better vasodilator effect than Vincamine (HY-B1021), but there is no significant difference in the protective effect of the two drugs against hypobaric hypoxia-induced lethality in mice[1]. | [References]
[1] Marzo, et al. A new phthalidyl derivative of apovincaminic acid:(3 alpha, 16 alpha)-eburnamenine-14 carboxylic acid phthalidyl ester (AF 698). A preliminary report on its chemical and pharmacological properties. Arzneimittel-forschung 32.6 (1982): 601-603. PMID:7202363 |
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