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83199-32-0

83199-32-0 Structure

83199-32-0 Structure
IdentificationBack Directory
[Name]

RP-TTP-ALPHA-S/RP-DTTP-ALPHA-S SODIUM SALT
[CAS]

83199-32-0
[Synonyms]

Sp-TTP-α-S
dTTPαS (Sp isomer) 100mM Sodium Solution
SP-TTP-ALPHA-S/SP-DTTP-ALPHA-S SODIUM SALT
RP-TTP-ALPHA-S/RP-DTTP-ALPHA-S SODIUM SALT
thymidine-5’-o-(1-thiotriphosphate),sp-isomer(sp-ttp-alpha-s),sodiumsalt
Thymidine, 5-P-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(S)(OH)2), (S)-
THYMIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER/2'-DEOXYTHYMIDINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
THYMIDINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER/2'-DEOXYTHYMIDINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT
[Molecular Formula]

C10H13N2Na4O13P3S
[MDL Number]

MFCD04118069
[MOL File]

83199-32-0.mol
[Molecular Weight]

586.16
Hazard InformationBack Directory
[Uses]

Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) catalysis inhibitor. Sp-TTPαS competitively inhibits TTP hydrolysis with a Ki value of 46 μM[1].
[References]

[1] Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60(21):1682-1698. DOI:10.1021/acs.biochem.0c00944
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