| Identification | Back Directory | [Name]
HC TOXIN | [CAS]
83209-65-8 | [Synonyms]
Toxin I
HC TOXIN
HC toxin I
Cyclo(aoe-Pro-Ala-ala)
HC TOXIN FROM HELMINTHOSPORIUM CARBONUM
Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID)
Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]
Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)
Cyclo(L-alanyl-D-alanyl-8-oxiranyl-8-oxo-L-2-aminooctanoyl-D-prolyl), (S)-
Cyclo(L-alanyl-D-alanyl-(alphas,2S)-alpha-amino-eta-oxooxiraneoctanoyl-D-prolyl)
(3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone | [Molecular Formula]
C21H32N4O6 | [MDL Number]
MFCD29924706 | [MOL File]
83209-65-8.mol | [Molecular Weight]
436.51 |
| Chemical Properties | Back Directory | [Boiling point ]
819.2±65.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10 mg/ml; Methanol: 10 mg/ml | [form ]
lyophilized powder | [pka]
13.33±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. | [Uses]
HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2) | [Definition]
ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues. | [Biochem/physiol Actions]
Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype. | [storage]
Store at -20°C | [References]
[1] G BROSCH. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum.[J]. Plant Cell, 1995, 7 11: 1941-1950. DOI: 10.1105/tpc.7.11.1941
[2] S J DARKIN-RATTRAY. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 23: 13143-13147. DOI: 10.1073/pnas.93.23.13143
[3] H. KAMITANI. Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.[J]. Carcinogenesis, 2001, 22 1 1: 187-191. DOI: 10.1093/carcin/22.1.187
[4] HUA CAO George S. Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin[J]. American Journal of Hematology, 2006, 81 12: 981-983. DOI: 10.1002/ajh.20676
[5] WALTON J. HC-toxin.[J]. Phytochemistry, 2020, 67 14 1: 1406-1413. DOI: 10.32388/5s7act |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|