| Identification | Back Directory | [Name]
PL017 | [CAS]
83397-56-2 | [Synonyms]
PL017
TYR-PRO-(NME)PHE-DPRO-NH2
morphiceptin, N-Me-Phe(3)-
[NMPhe3,D-Pro4]morphiceptin
H-TYR-PRO-N-ME-PHE-D-PRO-NH2
[N-ME-PHE3, D-PRO4]-MORPHICEPTIN
L-Tyr-L-Pro-N-Methyl-L-Phe-D-Pro-NH2
[(NME)PHE3, DPRO4] MORPHICEPTIN, BOVINE
[NMePhe3, DPro4] b-Casomorphin: 1-4, amide, bovine
{N-METHYL-PHE3,D-PRO4}-BETA-CASOMORPHIN FRAGMENT 1-
(N-Me-Phe3,D-Pro4)-β-Casomorphin (1-4) amide (bovine)
(N-ME-PHE3,D-PRO4)-BETA-CASOMORPHIN (1-4) AMIDE (BOVINE)
[n-methyl-phe3, d-pro4]-β-casomorphin fragment 1-4 amide, bovine | [Molecular Formula]
C29H37N5O5 | [MDL Number]
MFCD00135717 | [MOL File]
83397-56-2.mol | [Molecular Weight]
535.63 |
| Chemical Properties | Back Directory | [Boiling point ]
878.5±65.0 °C(Predicted) | [density ]
1.313±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
Powder | [pka]
9.86±0.15(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
PL-017 is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats[1]. | [Biological Activity]
PL-017 is a potent and selective μ opioid receptor agonist with IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ site. PL-017 produces durable and reversible analgesia in rats. | [in vitro]
PL-017 has an IC 50 of 10000 nM for 125 I-DADLE binding to δ site. | [in vivo]
PL-017 (0.22, 0.45, 0.9 nmol/rat; icv) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g. | [target]
IC50: 5.5 nM ( 125 I-FK 33,824 binding to μ site) | [References]
[1] K J Chang, et al. Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227(2):403-8. PMID:6313901 |
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BOC Sciences
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| Website: |
https://www.bocsci.com |
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