| Identification | Back Directory | [Name]
Benzeneacetic acid, 4-[[(1R,2S)-2-hydroxycyclopentyl]methyl]-α-methyl-, (αS)- | [CAS]
83648-76-4 | [Synonyms]
Loxoprofen Impurity 52
Benzeneacetic acid, 4-[[(1R,2S)-2-hydroxycyclopentyl]methyl]-α-methyl-, (αS)- | [Molecular Formula]
C15H20O3 | [MOL File]
83648-76-4.mol | [Molecular Weight]
248.32 |
| Chemical Properties | Back Directory | [Boiling point ]
418.6±20.0 °C(Predicted) | [density ]
1.189±0.06 g/cm3(Predicted) | [solubility ]
Acetonitrile: Soluble
Methanol: Soluble | [pka]
4.42±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Loxoprofenol-SRS, an active metabolite of Loxoprofen, is a new intravenous NSAID. Loxoprofenol-SRS exhibits significantly stronger anti-inflammatory and analgesic activities[1]. | [Definition]
ChEBI: (2S)-2-(4-{[(1R,2S)-2-hydroxycyclopentyl]methyl}phenyl)propanoic acid is a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-hydroxycyclopentyl)methyl]phenyl group (the 2S,1'R,2'S-stereoisomer. The active metabolite of loxoprofen. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a xenobiotic metabolite, a human metabolite and a drug metabolite. It is a monocarboxylic acid and a member of cyclopentanols. It is functionally related to a propionic acid and a loxoprofen. | [References]
[1] Hai Ye, et al. HR1405-01, a Safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials. Eur J Med Chem. 2022 May 5;235:114258. DOI:10.1016/j.ejmech.2022.114258 |
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