| Identification | Back Directory | [Name]
FA-PHE-PHE-OH | [CAS]
83661-95-4 | [Synonyms]
FAPP
FA-PHE-PHE-OH
3-(2-FURYL)-ACRYLOYL-PHE-PHE
3-(2-FURYL)ACRYLOYL-PHE-PHE-OH
N-(3-[2-FURYL]ACRYLOYL)-PHE-PHE
N-[3-(2-furyl)acryloyl]-phenylalanine-phenylalanine
N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-L-phenylalanine
N-[(2E)-3-(2-Furyl)-2-propenoyl]-L-phenylalanyl-L-phenylalanine
L-Phenylalanine, N-[3-(2-furanyl)-1-oxo-2-propen-1-yl]-L-phenylalanyl- | [Molecular Formula]
C25H24N2O5 | [MDL Number]
MFCD00057254 | [MOL File]
83661-95-4.mol | [Molecular Weight]
432.47 |
| Hazard Information | Back Directory | [Uses]
FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A[1][2]. | [References]
[1] Mayer M, et al. Mapping the active site of angiotensin-converting enzyme by transferred NOE spectroscopy. J Med Chem. 2000 Jun 1;43(11):2093-9. DOI:10.1021/jm990194x
[2] Ostrowska H, et al. Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem Biophys Res Commun. 1997 May 29;234(3):729-32. DOI:10.1006/bbrc.1997.6434 |
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