| Identification | Back Directory | [Name]
N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide | [CAS]
836640-15-4 | [Synonyms]
PARP1-IN-8
2(1H)-Phthalazinepropanamide, N-(3-chlorophenyl)-1-oxo-4-phenyl-
N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide
poly ADP ribose polymerase,phthalazinone,PARP,inhibit,HFF cells,Lung adenocarcinoma,Inhibitor,PARP1 IN 8?,PARP1IN8?,A549 cells | [Molecular Formula]
C23H18ClN3O2 | [MOL File]
836640-15-4.mol | [Molecular Weight]
403.86 |
| Chemical Properties | Back Directory | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 62.5 mg/mL (154.76 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.80±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PARP1-IN-8 (compound 11c) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 97 nM. PARP1-IN-8 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549[1]. | [IC 50]
PARP-1: 97 nM (IC50) | [storage]
4°C, protect from light | [References]
[1] Almahli H, Hadchity E, Jaballah MY, Daher R, Ghabbour HA, Kabil MM, Al-Shakliah NS, Eldehna WM. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456. DOI:10.1016/j.bioorg.2018.01.034 |
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