| Identification | Back Directory | [Name]
Roquinimex | [CAS]
84088-42-6 | [Synonyms]
FCF89
LS-2616
CS-1231
LINOMIDE
ABR212616
PNU 212616
ROQUINIMEX
Roquinimex(Linomide)
4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide
1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE
1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE
3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-
N-phenyl-N-Methyl-1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-quinoline-3-carboxaMide
N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE | [Molecular Formula]
C18H16N2O3 | [MDL Number]
MFCD00866331 | [MOL File]
84088-42-6.mol | [Molecular Weight]
308.33 |
| Chemical Properties | Back Directory | [Melting point ]
200-204° | [Boiling point ]
436.2±45.0 °C(Predicted) | [density ]
1.357±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: 11 mg/mL
| [form ]
solid
| [pka]
4.50±1.00(Predicted) | [color ]
White to off-white | [Merck ]
14,8259 |
| Hazard Information | Back Directory | [Description]
Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model. | [Uses]
Biological response modifier; immunomodulator. | [Definition]
ChEBI: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide is an aromatic amide. | [Biological Activity]
Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo . | [storage]
Store at -20°C | [References]
[1] N. ILB?CK. Effects of the immunomodulator LS 2616 on lymphocyte subpopulations in murine Coxsackievirus B3 myocarditis.[J]. Journal of immunology, 1989, 142 9 1: 3225-3228. DOI: 10.4049/jimmunol.142.9.3225
[2] ZHI-YONG XIAO. Roquinimex-mediated protection effect on the development of chronic graft-versus-host disease in mice is associated with induction of Th1 cytokine production and inhibition of proinflammatory cytokine production[J]. Life sciences, 2007, 81 19: Pages 1403-1410. DOI: 10.1016/j.lfs.2007.08.044
[3] Q LIU. Roquinimex inhibits dextran sodium sulfate-induced murine colitis.[J]. Inflammation Research, 2003, 52 2: 64-68. DOI: 10.1007/s000110300002
[4] D J GROSS. The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice.[J]. Clinical Cancer Research, 1999, 5 11: 3669-3675.
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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