| Identification | Back Directory | [Name]
Acetamide, N-[3-(acetylamino)phenyl]-2-[[5-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]- | [CAS]
841210-82-0 | [Synonyms]
Compound 10
Acetamide, N-[3-(acetylamino)phenyl]-2-[[5-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]- | [Molecular Formula]
C22H19N5O2S | [MOL File]
841210-82-0.mol | [Molecular Weight]
417.48 |
| Hazard Information | Back Directory | [Description]
NFAT:AP-1 inhibitor-10 is a novel inhibitor of the NFAT:AP-1:DNA interaction on the ARRE-2 element, binding to DNA in a sequence-selective manner and inhibiting the transcription of the Il2 gene and several other cyclosporin A-sensitive cytokine genes important for the effector immune response. | [Uses]
NFAT Inhibitor-3 (Compound 10) is a factor nuclear factor of activated T cells (NFAT) inhibitor. NFAT Inhibitor-3 inhibits IL-2 production. NFAT Inhibitor-3 binds in a sequence-selective manner directly to DNA. NFAT Inhibitor-3 can be used for the research of transcription factor dysregulation[1]. | [References]
[1] Mognol GP, et al. Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9959-9968. DOI:10.1073/pnas.1820604116 |
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