| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 7-[2-(dimethylamino)ethoxy]-5-hydroxy-2-phenyl- | [CAS]
84212-49-7 | [Synonyms]
AChE/BuChE-IN-1
4H-1-Benzopyran-4-one, 7-[2-(dimethylamino)ethoxy]-5-hydroxy-2-phenyl- | [Molecular Formula]
C19H19NO4 | [MOL File]
84212-49-7.mol | [Molecular Weight]
325.36 |
| Hazard Information | Back Directory | [Uses]
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC50 of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC50 of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC50 of 0.1674?μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ1-42 aggregation (self-, Cu2+-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has?the?potential?for?Alzheimer' disease (AD)?research[1]. | [IC 50]
AChE | [References]
[1] Aihong Yang, et al. A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives. Eur J Med Chem. 2022 Apr 5;233:114216. DOI:10.1016/j.ejmech.2022.114216 |
|
|