| Identification | Back Directory | [Name]
FC131 TFA (606968529 free base),FC131 TFA (606968 52 9 free base),FC-131 TFA (606968-52-9 free base) | [CAS]
842166-42-1 | [Synonyms]
FC131 TFA (606968-52-9 free base)
FC131 TFA (606968529 free base),FC131 TFA (606968 52 9 free base),FC-131 TFA (606968-52-9 free base) |
| Hazard Information | Back Directory | [Uses]
FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity[1]. | [IC 50]
125I-SDF-1-CXCR4: 4.5 nM (IC50); HIV | [References]
[1] Tamamura H, et al. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27;48(2):380-91. DOI:10.1021/jm049429h |
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