| Identification | Back Directory | [Name]
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- | [CAS]
844441-56-1 | [Synonyms]
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- | [Molecular Formula]
C17H18F2N4O3 | [MOL File]
844441-56-1.mol | [Molecular Weight]
364.35 |
| Chemical Properties | Back Directory | [Boiling point ]
539.9±50.0 °C(Predicted) | [density ]
1.389±0.06 g/cm3(Predicted) | [solubility ]
DMSO: 2 mg/mL, clear | [form ]
powder | [pka]
10.80±0.70(Predicted) | [color ]
white to beige | [SMILES]
O=C(NCC1CCOCC1)C2=NNC=C2NC(C3=C(C=CC=C3F)F)=O |
| Hazard Information | Back Directory | [Uses]
GSK3-IN-10 (Compound 4) is a multi-target inhibitor, that mainly targets GSK3α and GSK3β with IC50 of 1.0 nM and 2.0 nM. GSK3-IN-10 inhibits the activation of β-catenin, promotes the neuronal survival, and exhibits a protective effect against endoplasmic reticulum stress[1]. | [IC 50]
GSK-3α: 1.0 nM (IC50); GSK-3β: 2.0 nM (IC50); DYRK1B: 47 nM (IC50); DYRK1A: 170 nM (IC50); ICK: 520 nM (IC50); CLK1: 620 nM (IC50); CLK4: 760 nM (IC50); DYRK2: 800 nM (IC50); CLK2: 800 nM (IC50); CDKL5: 840 nM (IC50); JNK3: 2900 nM (IC50); CDK4: 3800 nM (IC50) | [References]
[1] Ong HW, et al., Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS Chem Neurosci. 2023 May 3;14(9):1672-1685. DOI:10.1021/acschemneuro.3c00135 |
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TargetMol
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