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Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease[1][2]. | [in vivo]
Atacicept (TACI-Ig; 100 μg; i.p.; three times of week for 14 days; BALB/c mice) reduces mature B-cell counts and serum antibody levels in normal mice[1].
Atacicept (TACI-Ig) inhibits the progression of disease and autoantibody titers in a mouse model of collagen-induced arthritis (CIA)[1].
| Animal Model: | Male DBA/1 mice with CIA models[1] | | Dosage: | 100 μg | | Administration: | intraperitoneal injection; three times of week for 21 days | | Result: | Increased serum titers of anti-collagen Abs and few overt signs of disease. |
| Animal Model: | BALB/c mice[1] | | Dosage: | 100 μg | | Administration: | intraperitoneal injection; three times of week for 14 days | | Result: | Reduced mature B cell populations but had little effect on other cell lineages.
Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen.
Decerased the serum levels of IgM about 2.3-fold.
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| [References]
[1] Gross JA, et, al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity. 2001 Aug;15(2):289-302. DOI:10.1016/s1074-7613(01)00183-2
[2] Gross JA, et, al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000 Apr 27;404(6781):995-9. DOI:10.1038/35010115 |
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