| Chemical Properties | Back Directory | [Boiling point ]
583.4±50.0 °C(Predicted) | [density ]
1.381±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.5 mg/ml | [form ]
A crystalline solid | [pka]
4.15±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
AAT-008 is an antagonist for the PGE2 receptor EP4. | [Uses]
AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively[1]. | [IC 50]
EP4: 0.97 nM (Ki); EP4: 6.1 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Okumura Y, et al. Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorg Med Chem Lett. 2017;27(5):1186-1192. DOI:10.1016/j.bmcl.2017.01.067 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Boao Pike
|
| Tel: |
010-57798038 15652371397 |
| Website: |
www.biopike.cn |
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