| Identification | Back Directory | [Name]
EX527 | [CAS]
848193-68-0 | [Synonyms]
EX527
CS-573
EX-527(S)
(S)-Selisistat
EX-527 (S-enantioMer)
Selisistat S-enantiomer
Selisistat S-enantiomer(EX-527 S-enantiomer)
(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1S)-
EX-527(S); (S)-SELISISTAT; EX 527(S); EX527(S); EX-527S; EX527S;
EX-527(S),(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide | [Molecular Formula]
C13H13ClN2O | [MDL Number]
MFCD20503073 | [MOL File]
848193-68-0.mol | [Molecular Weight]
248.71 |
| Chemical Properties | Back Directory | [Boiling point ]
531.7±38.0 °C(Predicted) | [density ]
1.388 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
16.12±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM. | [Definition]
ChEBI:(S)-selisistat is a 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has S configuration It is the active enantiomer. It has a role as a Sir1 inhibitor. It is an enantiomer of a (R)-selisistat. | [in vivo]
(S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group[3]. | [IC 50]
SIRT1: 98 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. DOI:10.1128/MCB.26.1.28-38.2006
[2] Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. DOI:10.1371/journal.pone.0120849
[3] Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. DOI:10.1002/oby.21086
[4] Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|