| Identification | Back Directory | [Name]
315224-26-1 (free) | [CAS]
849738-78-9 | [Synonyms]
AMG-131
AMG-131 besylate
315224-26-1 (free)
AMG-131 849738-78-9 | [Molecular Formula]
C27H18Cl4N2O6S2 | [MDL Number]
MFCD32204186 | [MOL File]
849738-78-9.mol | [Molecular Weight]
672.37 |
| Hazard Information | Back Directory | [Uses]
AMG131 (INT131) (benzenesulfonate) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 (benzenesulfonate) binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 (benzenesulfonate) is promising for research of type-2 diabetes mellitus[1][2][3]. | [References]
[1] Linda S Higgins,et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906. DOI:10.1155/2008/936906
[2] Alykhan Motani, et al. INT131: a selective modulator of PPAR gamma. J Mol Biol. 2009 Mar 13;386(5):1301-11. DOI:10.1016/j.jmb.2009.01.025
[3] Higgins LS, et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906. DOI:10.1155/2008/936906 |
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