| Identification | Back Directory | [Name]
ML604086 | [CAS]
850330-18-6 | [Synonyms]
ML604086
Benzamide, N-[4-[[[(3R,4R)-1-[(2S)-2-amino-1-oxopropyl]-3-methyl-4-piperidinyl]amino]sulfonyl]-1-naphthalenyl]-2-methyl- | [Molecular Formula]
C27H32N4O4S | [MDL Number]
MFCD32201065 | [MOL File]
850330-18-6.mol | [Molecular Weight]
508.63 |
| Hazard Information | Back Directory | [Description]
ML604086 is a selective inhibitor of schemokine receptor CCR8. | [Uses]
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations[1][2]. | [in vivo]
ML604086 (1.038 mg/kg; intravenous infusion) shows no effect on airway eosinophilia, pro-inflammatory cytokine production or airway resistance and compliance in Macaca fascicularis[1]. | Animal Model: | 3.0-5.0 kg male and female adult Macaca fascicularis (primate model
of asthma)[2] | | Dosage: | 1.038 mg/kg | | Administration: | Intravenous infusion | | Result: | Did not effected the Changes in airway resistance and compliance induced by allergen provocation and increasing concentrations of methacholine. |
| [IC 50]
CCR8 | [References]
[1] James E. Pease, et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. Top Med Chem (2015) 14: 1-40.
[2] Lin Wang, et al. Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma. Thorax 2013;68:506–512. |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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