| Identification | Back Directory | [Name]
BREVETOXIN PBTX-3 | [CAS]
85079-48-7 | [Synonyms]
PBTX-3
toxint-17
Gb 3 toxin
BREVETOXIN3
PUMILIOTOXIN
brevetoxint17
BREVETOXIN PBTX-3
DIHYDROBREVETOXIN B
BKMHDYJRAAJTAD-RXUQWMQDSA-N
42-Deoxo-42-hydroxybrevetoxin B
42-Hydroxy-42-deoxobrevetoxin B
Brevetoxin B, 42-deoxo-42-hydroxy-
BREVETOXIN PBTX-3, PTYCHODISCUS BREVIS
Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem | [Molecular Formula]
C50H72O14 | [MDL Number]
MFCD00214096 | [MOL File]
85079-48-7.mol | [Molecular Weight]
897.1 |
| Chemical Properties | Back Directory | [density ]
1.190±0.06 g/cm3(Predicted) | [storage temp. ]
-20C | [solubility ]
DMSO: soluble,Ethanol: soluble,Methanol: soluble | [form ]
Solid | [pka]
13.78±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
BKMHDYJRAAJTAD-FGRVLNGBSA-N |
| Safety Data | Back Directory | [RIDADR ]
3172 | [WGK Germany ]
WGK 2 | [RTECS ]
XW5885000 | [HazardClass ]
6.1(a) | [PackingGroup ]
I | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2 | [Safety Profile]
A poison by ingestion,
intraperitoneal, and intravenous routes.
When heated to decomposition it emits
acrid smoke and irritating vapors. |
| Hazard Information | Back Directory | [Uses]
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+?channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2]. | [General Description]
Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites. | [Biochem/physiol Actions]
Primary TargetVoltage-dependent Na+ channel activator | [in vivo]
Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18)?radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues[3].
. | Animal Model: | Pregnant CD-1 mice[3] | | Dosage: | 2.8 μg/kg | | Administration: | Intratracheal instillation; 2.8 μg/kg; gestational days 15–18 | | Result: | Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure.? |
| [References]
[1] Jeglitsch G,et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.J Pharmacol Exp Ther. 1998 Feb;284(2):516-25. PMID:9454792
[2] Zaias J,et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.Inhal Toxicol. 2011 Mar;23(4):205-11. DOI:10.3109/08958378.2011.558936
[3] Benson JM, et al. Placental transport of brevetoxin-3 in CD-1 mice.Toxicon.?2006 Dec 15;48(8):1018-26. Epub 2006 Aug 18. DOI:10.1016/j.toxicon.2006.08.008 |
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