| Identification | Back Directory | [Name]
2-bromo-4-(trifluoromethyl)benzaldehyde | [CAS]
85118-24-7 | [Synonyms]
Einecs 285-677-2
3-Bromo-4-formylbenzotrifluoride
-bromo-4-(trifluoromethyl)benzaldehyde
2-bromo-4-(trifluoromethyl)benzaldehyde
Benzaldehyde, 2-bromo-4-(trifluoromethyl)- | [EINECS(EC#)]
285-677-2 | [Molecular Formula]
C8H4BrF3O | [MDL Number]
MFCD09835101 | [MOL File]
85118-24-7.mol | [Molecular Weight]
253.016 |
| Chemical Properties | Back Directory | [Boiling point ]
230.0±40.0℃ (760 Torr) | [density ]
1.677±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
92.9±27.3℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
liquid | [color ]
Clear, faint yellow |
| Hazard Information | Back Directory | [Uses]
2-Bromo-4-(trifluoromethyl)benzaldehyde is a fluorobenzaldehyde analogue that is used as an organic synthesis intermediate. | [Synthesis]
At low temperatures, the raw material is treated with n-butyllithium (n-BuLi). Due to the ortho-position directional activation of trifluoromethyl (-CF3), the bromine atom located adjacent to it is preferentially exchanged with lithium to form an aryllithium intermediate. Subsequently, N,N-dimethylformamide (DMF) is added for a formylation reaction, and finally, acidic hydrolysis yields the target product 2-Bromo-4-(trifluoromethyl)benzaldehyde. |
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