| Identification | Back Directory | [Name]
4-Pyrimidinamine, 6-methyl-N-(5-methyl-1H-pyrazol-3-yl)-2-[(2S)-2-[3-(2-pyridinyl)-5-isoxazolyl]-1-pyrrolidinyl]- | [CAS]
851432-37-6 | [Synonyms]
AZ12253801
AZ-12253801
AZ 12253801
4-Pyrimidinamine, 6-methyl-N-(5-methyl-1H-pyrazol-3-yl)-2-[(2S)-2-[3-(2-pyridinyl)-5-isoxazolyl]-1-pyrrolidinyl]- | [Molecular Formula]
C21H22N8O | [MOL File]
851432-37-6.mol | [Molecular Weight]
402.45 |
| Hazard Information | Back Directory | [Description]
AZ12253801 is an inhibitor of the type 1 insulin-like growth factor receptor (IGF-1R). | [Uses]
AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ～10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50?for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity. | [References]
[1] https://aacrjournals.org/cancerres/article/70/16/6412/559448/Type-1-Insulin-like-Growth-Factor-Receptor |
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