| Identification | Back Directory | [Name]
OC000459 | [CAS]
851723-84-7 | [Synonyms]
OC-459
CS-581
OC000459
OC000495
OC000459, >=98%
OC000459 USP/EP/BP
OC000459(Timapiprant)
OC000459;OC-000459; OC 000459
[5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid
5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid
1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-
5-Fluoro-2-Methyl-3-quinolin-2-ylMethylindo-1-yl)-acetic(OC000459)
2-[5-FLUORO-2-METHYL-3-(QUINOLIN-2-YLMETHYL)INDOL-1-YL]ACETIC ACID
(5-Fluoro-3-isoquinolin-3-ylMethyl-2-Methyl-indol-1-yl)-acetic acid
2-(5-fluoro-2-Methyl-3-(quinolin-
2-ylMethyl)-1H-indol-1-yl)acetic
acid
[5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid OC000459 | [Molecular Formula]
C21H17FN2O2 | [MDL Number]
MFCD18633254 | [MOL File]
851723-84-7.mol | [Molecular Weight]
348.37 |
| Chemical Properties | Back Directory | [Boiling point ]
574.4±50.0 °C(Predicted) | [density ]
1.29 | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 0.5 mg/ml; DMSO: 1.1 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
4.08±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
OC000459 is a CRTH2 antagonist which helps in the treatment of allergies, reducing nasal and ocular symptoms in subjects exposed to allergens. | [in vivo]
Timapiprant (OC000459) (gavage; 2 mg/kg, 10 mg/kg) inhibits blood eosinophilia induced by 13,14-dihydro-15-keto-PGD2 (DK-PGD2) in Rat (ED50=0.04 mg/kg)[1].
Timapiprant (OC000459) (gavage; 0.01 mg/kg, 0.1 mg/kg, 1.0 mg/kg) inhibits airway eosinophilia in response to an aerosol of DK-PGD2 in guinea pigs (ED50=0.01 mg/kg)[1]. | [IC 50]
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