| Identification | Back Directory | [Name]
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1) | [CAS]
85187-37-7 | [Synonyms]
Cloperastine fendiz
Cloperastine fendizoate
Cloperastine Febdizoate
Levocloperastine Fendizoate
Levocloperastine Fendizoate Racemic Impurity
1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate
1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1) ISO 9001：2015 REACH | [EINECS(EC#)]
286-126-9 | [Molecular Formula]
C40H38ClNO5 | [MDL Number]
MFCD01661515 | [MOL File]
85187-37-7.mol | [Molecular Weight]
648.186 |
| Chemical Properties | Back Directory | [Melting point ]
185-187°C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Cloperastine fendizoate is used in the treatment of chronic non-productive cough. Antitussive. it is the salt of Cloperastine (CAS:3703-76-2) | [Definition]
ChEBI: Cloperastine fendizoate is a N-oxyethylpiperidine. It is functionally related to a benzoate. | [in vivo]
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic
action potential (MAP) duration without affecting PR interval or QRS width[1]. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively[2]. |
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