| Identification | Back Directory | [Name]
(R)-ADX-47273 | [CAS]
851881-59-9 | [Synonyms]
(R)-ADX-47273
Inhibitor,inhibit,mGluR,(R)ADX47273,(R) ADX 47273,Metabotropic glutamate receptors
(4-Fluorophenyl)[(3R)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone
Methanone, (4-fluorophenyl)[(3R)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]- | [Molecular Formula]
C20H17F2N3O2 | [MOL File]
851881-59-9.mol | [Molecular Weight]
369.36 |
| Hazard Information | Back Directory | [Description]
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
mGluR5|168 nM (EC50)
(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1]. | [Uses]
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation . | [IC 50]
mGlu5: 168 nM (EC50) | [References]
[1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11. |
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