| Identification | Back Directory | [Name]
FLT3 Inhibitor III | [CAS]
852045-46-6 | [Synonyms]
MDK5466
MDK-5466
MDK 5466
Flt3-IN-III
FLT3 Inhibitor III | [Molecular Formula]
C21H23N3OS | [MDL Number]
MFCD24369051 | [MOL File]
852045-46-6.mol | [Molecular Weight]
365.49 |
| Chemical Properties | Back Directory | [Boiling point ]
554.1±60.0 °C(Predicted) | [density ]
1.219±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.25 mg/ml; Ethanol: 20 mg/ml | [form ]
A crystalline solid | [pka]
9.65±0.20(Predicted) | [color ]
off-white |
| Hazard Information | Back Directory | [Description]
FLT3 Inhibitor III is a potent inhibitor of Fms-like tyrosine kinase 3 (FLT3; IC50 = 50 nM). It shows high selectivity for FLT3 over a panel of 300 other kinases. FLT3 Inhibitor III blocks FLT-dependent cell proliferation in a dose-dependent manner. FLT3 Inhibitor III has been used to study signaling through FLT3 and FLT3 with internal tandem duplications (FLT3-ITD) in cells. | [Uses]
Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects[1]. | [IC 50]
Tie2: 8.0 μM (IC50) | [References]
[1] Pascal Furet, et al. Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. J Med Chem. 2006 Jul 27;49(15):4451-4. DOI:10.1021/jm060368s |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Boao Pike
|
| Tel: |
010-57798038 15652371397 |
| Website: |
www.biopike.cn |
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