| Identification | Back Directory | [Name]
LASSBio-1135 | [CAS]
852453-71-5 | [Synonyms]
LASSBio-1135
Imidazo[1,2-a]pyridin-3-amine, N-phenyl-2-(2-pyridinyl)- | [Molecular Formula]
C18H14N4 | [MOL File]
852453-71-5.mol | [Molecular Weight]
286.33 |
| Hazard Information | Back Directory | [Description]
LASSBio-1135 is a dual TRPV1 antagonist and TNF-alpha production inhibitor. | [Uses]
LASSBio-1135 (Compound 3a) is an orally active TRPV1 antagonist. LASSBio-1135 is an anti-inflammatory and analgesic compound. LASSBio-1135 inhibits moderately the human PGHS-2 enzyme activity (IC50 = 18.5 μM). LASSBio-1135 reverts the Capsaicin (HY-10448)-induced thermal hyperalgesia and reduces the carrageenan-induced rat paw edem[1]. | [References]
[1] Lacerda RB, et al. Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes. Bioorg Med Chem. 2009 Jan 1;17(1):74-84. DOI:10.1016/j.bmc.2008.11.018
[2] Lima CK, et al. LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain. PLoS One. 2014 Jun 18;9(6):e99510. DOI:10.1371/journal.pone.0099510 |
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| Company Name: |
Alomone Labs
|
| Tel: |
4008-168-068 13121892008 |
| Website: |
www.alomone.com |
|