| Identification | Back Directory | [Name]
2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline | [CAS]
85273-95-6 | [Synonyms]
ZM 169369
ICI-169369
2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline
N,N-Dimethyl-2-[(3-phenylquinolin-2-yl)thio]ethanamine
Ethanamine, N,N-dimethyl-2-[(3-phenyl-2-quinolinyl)thio]- | [Molecular Formula]
C19H20N2S | [MDL Number]
MFCD28047481 | [MOL File]
85273-95-6.mol | [Molecular Weight]
308.44 |
| Hazard Information | Back Directory | [Uses]
ICI 169369 (free base) is an orally active, selective and non-competitive antagonist against 5HT receptor. ICI 169369 (free base) blunts the vasopressin (AVP), but not the ACTH, prolactin or growth hormone reponses to insulin-induced hypoglycaemia. ICI 169369 (free base) blocks centrally mediated 5-HT responses and lowers portal pressure in portal hypertensive rats[1][2][3][4]. | [References]
[1] Thompson CJ, et al. The effects of the specific serotonin antagonist ICI 169,369 on the pituitary hormone response to insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf). 1992 Mar;36(3):235-40. DOI:10.1111/j.1365-2265.1992.tb01438.x
[2] Blackburn TP, et al. In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist. Eur J Pharmacol. 1988 Jun 10;150(3):247-56. DOI:10.1016/0014-2999(88)90005-2
[3] Kaumann A J, et al. ICI 169,369 selectively blocks 5-hydroxytryptamine2 receptors and lowers portal pressure in portal hypertensive rats[J]. Gastroenterology, 1988, 95(6): 1601-1606. DOI:10.1016/s0016-5085(88)80084-2
[4] Blackburn TP, et al. Pharmacological studies in vivo with ICI 169,369, a chemically novel 5-HT2/5-HT1C receptor antagonist. Eur J Pharmacol. 1990 May 16;180(2-3):229-37. DOI:10.1016/0014-2999(90)90306-q |
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