| Identification | Back Directory | [Name]
N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide | [CAS]
852846-00-5 | [Synonyms]
SA-15-P
N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide | [Molecular Formula]
C26H24N2O4 | [MOL File]
852846-00-5.mol | [Molecular Weight]
428.48 |
| Chemical Properties | Back Directory | [Boiling point ]
566.0±50.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
12.23±0.70(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies[1]. | [Biological Activity]
SA-15-P is a LAG-3 (CD223) inhibitor th at blocks LAG-3 interactions with both major histocompatibility complex class II and fibrinogen-like protein 1 by cell-free (MHCII IC50 = 4.21 μM & FGL1 IC50 = 6.52 μM) and cell-based binding assays (IC50 ~15 μM against 150 ng/mL or 1.5 nM FGL1-hFc binding to stable LAG-3-expressing CHO-K1 cell line). | [References]
[1] Abdel-Rahman SA, et al. Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3). ACS Med Chem Lett. 2023 Apr 11;14(5):629-635. DOI:10.1021/acsmedchemlett.3c00054 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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