| Identification | Back Directory | [Name]
1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE | [CAS]
85375-15-1 | [Synonyms]
skf-89976a
SKF89976AHCl
SKF 89976A HYDROCHLORIDE
l-SKF89976A hydrochloride
d,l-SKF89976A hydrochloride
1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride
1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride | [Molecular Formula]
C22H26ClNO2 | [MDL Number]
MFCD01321071 | [MOL File]
85375-15-1.mol | [Molecular Weight]
371.9 |
| Hazard Information | Back Directory | [Uses]
SKF-89976A is a GABA transporters (GATs) type 1 inhibitor. | [Biological Activity]
A potent GABA uptake inhibitor, selective for GAT-1 (IC 50 values are 0.13, 550, 944 and 7210 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K i = 7 μ M) and transmitter-gated current non-competitively (K i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo . | [in vivo]
SKF89976A produces a weak antiallodynic response when administered i.v. (0.3 mg/kg). The i.t. injection of SKF89976A dose-dependently ameliorates the reduction in the withdrawal threshold in PSL model mice[1]. | [storage]
+4°C (desiccate) |
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