| Identification | Back Directory | [Name]
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin hydrochloride | [CAS]
85378-82-1 | [Synonyms]
(+)-AJ 76 (hydrochloride)
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin hydrochloride | [Molecular Formula]
C15H24ClNO | [MDL Number]
MFCD00672685 | [MOL File]
85378-82-1.mol | [Molecular Weight]
269.81 |
| Hazard Information | Back Directory | [Description]
Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively). | [Uses]
AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) is an antagonist of dopamine autoreceptor with pKi values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hD3, hD4, hD2S, hD2L and rD2 receptors, respectively. | [Definition]
ChEBI:(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin hydrochloride is a hydrochloride obtained by reaction of (1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin with one equivalent of hydrochloric acid. Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively). It has a role as a dopaminergic antagonist. It contains a (1S,2R)-5-methoxy-1-methyl-2-(propylammonio)tetralin(1+). | [References]
[1] Kullingsj? H, et al. Effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur J Pharmacol. 1991 Dec 3;205(3):241-6. DOI:10.1016/0014-2999(91)90904-5 |
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