| Identification | Back Directory | [Name]
Indanidine | [CAS]
85392-79-6 | [Synonyms]
Indanidine
Indanidinum
Unii-mp564ife34
Indanidine [inn]
4-(2-Imidazolin-2-ylamino)-2-methyl-2H-imidazole
N-(2-Imidazolin-2-yl)-2-methyl-2H-indazol-4-amine
2H-Imidazole, 4-(2-imidazolin-2-ylamino)-2-methyl-
N-(4,5-Dihydro-1H-imidazol-2-yl)-2-methyl-2H-indazol-4-amine
2H-Indazol-4-amine, N-(4,5-dihydro-1H-imidazol-2-yl)-2-methyl- | [Molecular Formula]
C11H13N5 | [MDL Number]
MFCD00865960 | [MOL File]
85392-79-6.mol | [Molecular Weight]
215.25 |
| Chemical Properties | Back Directory | [Boiling point ]
413.3±37.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.83±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Indanidine is an alpha-adrenergic agonist. | [in vivo]
The selective alpha 1-adrenoceptor agonist, Indanidine, also behaved as a partial agonist in the aorta and produced no significant contractions of the small mesenteric artery. Since Idazoxan and Indanidine have been reported to raise blood pressure in the pithed rat via an action at vascular alpha 1-adrenoceptors, these results call into question the reliability of the small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity in vivo[1]. | [References]
[1] Van der Graaf PH, et al. Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity. Naunyn Schmiedebergs Arch Pharmacol. 1996 DOI:10.1007/BF00171074 |
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