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854924-64-4

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854924-64-4 Structure

854924-64-4 Structure
IdentificationBack Directory
[Name]

ST 198
[CAS]

854924-64-4
[Synonyms]

[Molecular Formula]

C22H26N2O
[MDL Number]

MFCD12546326
[MOL File]

854924-64-4.mol
[Molecular Weight]

334.45
Chemical PropertiesBack Directory
[Boiling point ]

556.2±50.0 °C(Predicted)
[density ]

1.093±0.06 g/cm3(Predicted)
[pka]

15.30±0.46(Predicted)
Hazard InformationBack Directory
[Description]

ST-198 is anantagonist of dopamine D3 receptor.
[Uses]

ST 198 is an orally active D3R antagonist. ST 198 can block the expression of nicotine-induced CPP at doses selective for D3R. ST 198 can be used for the research of neurological disease[1].
[in vivo]

ST 198 (p.o.; 3, 30, 100 mg/kg) inhibits the expression of nicotine CPPs[1].

Animal Model:Rats[1].
Dosage:3, 30, 100 mg/kg
Administration:p.o
Result:Displayed nicotine-induced CPP.
[References]

[1] Le Foll B, et al. Dopamine D3 receptor ligands block nicotine-induced conditioned place preferences through a mechanism that does not involve discriminative-stimulus or antidepressant-like effects. Neuropsychopharmacology. 2005;30(4):720-730. DOI:10.1038/sj.npp.1300622
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