| Identification | Back Directory | [Name]
(2S)-6-[(1S,5R,6S)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-(4-methylpent-3-enyl)cyclohex-2-en-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one | [CAS]
85698-31-3 | [Synonyms]
sanggenone G
(2S)-6-[(1S,5R,6S)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-(4-methylpent-3-enyl)cyclohex-2-en-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one | [Molecular Formula]
C40H38O11 | [MOL File]
85698-31-3.mol | [Molecular Weight]
694.723 |
| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [InChIKey]
VYCKCQBOVSSJSK-ZQRLWWEZNA-N | [SMILES]
[C@H]1(C2=CC=C(O)C=C2O)OC2=C(C(O)=C([C@@H]3[C@@H](C(=O)C4=CC=C(O)C=C4O)[C@H](C4=CC=C(O)C=C4O)CC(CC/C=C(\C)/C)=C3)C(O)=C2)C(=O)C1 |&1:0,15,16,27,r| |
| Hazard Information | Back Directory | [Uses]
Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP). Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation[1]. | [IC 50]
Caspase-3; Caspase-8; Caspase-9 | [References]
[1] Seiter MA, et al. Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP). FEBS Open Bio. 2014 Jul 5;4:659-71. DOI:10.1016/j.fob.2014.07.001 |
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