| Identification | Back Directory | [Name]
2-AMINO-4-METHOXYCARBONYL BENZOIC ACID | [CAS]
85743-02-8 | [Synonyms]
2-Carboxy-5-(methoxycarbonyl)aniline
2-AMINO-4-METHOXYCARBONYL BENZOIC ACID
2-amino-benzene-1,4-dicarboxylic acid,4-methyl ester
1,4-Benzenedicarboxylic acid, 2-amino-, 4-methyl ester | [Molecular Formula]
C9H9NO4 | [MDL Number]
MFCD08690068 | [MOL File]
85743-02-8.mol | [Molecular Weight]
195.17 |
| Chemical Properties | Back Directory | [Melting point ]
213 °C | [Boiling point ]
397.7±32.0 °C(Predicted) | [density ]
1.373±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
4.51±0.10(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Methyl 3-Amino-4-carboxybenzoate is an intermediate used to prepare (N-methylpiperazinyl)-contg. derivatives of quinazolinone as fungal efflux pump inhibitors. | [Synthesis]
General procedure for the synthesis of 2-amino-4-methoxycarbonylbenzoic acid from methyl 3-nitro-4-carboxybenzoate: preparation Example 12 Step 1. A suspension of 2-amino-4-(methoxycarbonyl)benzoic acid 12BA (4-methoxycarbonyl)-2-nitrobenzoic acid (12A) (10.0 g, 44.4 mmol) with 5% Pd/C (4.0 g) was reacted in a 1. 1 MeOH/H2O (50 mL) were mixed and placed under hydrogenation conditions (H2, 50 psi) for 16 hrs of reaction. Upon completion of the reaction, the mixture was filtered through a Celite pad, washed with MeOH, and the filtrate was concentrated to give the product 12B (6.51 g, yield = 75%). Mass spectral analysis showed MS (M+H) = 196. | [References]
[1] Patent: WO2012/51036, 2012, A1. Location in patent: Page/Page column 79
[2] Patent: US5541178, 1996, A
[3] Monatshefte fuer Chemie, 1907, vol. 28, p. 822 |
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| Company Name: |
Shanghai Uchem Inc.
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15618758386 15618758386 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList15300/0_EN.htm |
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