| Identification | Back Directory | [Name]
PSN632408 | [CAS]
857652-30-3 | [Synonyms]
PSN632408
PSN 632408; PSN-632408; PSN 632408; PSN-632408
tert-butyl 4-((3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)methoxy)piperidine-1-carboxylate
1-Piperidinecarboxylic acid, 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C18H24N4O4 | [MDL Number]
MFCD09297322 | [MOL File]
857652-30-3.mol | [Molecular Weight]
360.41 |
| Chemical Properties | Back Directory | [Boiling point ]
513.8±60.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
crystalline solid | [pka]
0.79±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
psn632408 is a novel, selective and small-molecule agonist of human and mouse gpr119 with ec50 values of 5.6±0.99 μm and 7.9±0.7 μm, respectively [1].psn632408 has been reported to activate human and mouse gpr119 in a yeast fluorimetric assay with ec50 of 5.6±0.99 μm and 7.9±0.7 μm, respectively. in hek-osgpr116 cells, camp level was dose-dependently increased by psn632408 with an ec50 of 1.9±0.14 μm.. in vivo, psn632408 induced food intake reduction by using a rat feeding model and acute hypophagic effects in dose-dependence [1]. | [References]
[1] overton ha1, babbs aj, doel sm, fyfe mc, gardner ls, griffin g, jackson hc, procter mj, rasamison cm, tang-christensen m, widdowson ps, williams gm, reynet c.deorphanization of a g protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. cell metab. 2006 mar;3(3):167-75 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
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| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
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