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857758-13-5

857758-13-5 Structure

857758-13-5 Structure
IdentificationBack Directory
[Name]

12R-LOX-IN-1
[CAS]

857758-13-5
[Synonyms]

12R-LOX-IN-1
Hazard InformationBack Directory
[Uses]

12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].
[References]

[1] Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606. DOI:10.1016/j.bioorg.2023.106606
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