| Identification | Back Directory | [Name]
DNP-PEG4-NHS ester | [CAS]
858126-78-0 | [Synonyms]
DNP-PEG4-NHS
DNP-NH-PEG(4)-NHS
DNP-PEG4-NHS ester
DNP-dPEG??-NHS ester
1-(2,4-Dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid succinimidyl ester
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
2,5-Pyrrolidinedione,1-[3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropoxy]-
2,5-Pyrrolidinedione, 1-[3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropoxy]- (9CI) | [Molecular Formula]
C21H28N4O12 | [MDL Number]
MFCD13184987 | [MOL File]
858126-78-0.mol | [Molecular Weight]
528.47 |
| Hazard Information | Back Directory | [Description]
DNP-PEG4-NHS ester is a PEG linker containing a DNP moiety and NHS ester terminal group. DNP is involved in biological applications such as participating in ion transport across membranes. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media. | [Uses]
DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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