| Identification | Back Directory | [Name]
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 2-methyl- | [CAS]
858275-30-6 | [Synonyms]
2-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
2-methyl-1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 2-methyl- | [Molecular Formula]
C9H8N2O | [MDL Number]
MFCD11616737 | [MOL File]
858275-30-6.mol | [Molecular Weight]
160.17 |
| Chemical Properties | Back Directory | [Melting point ]
210-212 °C(Solv: hexane (110-54-3)) | [density ]
1.301±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
solid | [pka]
12.96±0.40(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
b) Synthesis of 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
2-Methyl-7-azaindole (835 mg) was dissolved in a solvent mixture of 5.3 mL of water and 1.6 mL of ethyl acetate, followed by the addition of 1.32 g of urotropine (1,3,5,7-tetraazatricyclo[3.3.1.1^3,7]decane). The reaction mixture was reacted according to the conditions described in Example 2. Upon completion of the reaction, 580 mg of a mixture containing 60% 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde was obtained, the product being a beige solid.
The identification data of 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde is given below:
LC/MS (1): retention time: 1.7 minutes
Mass spectrum (1): (ES+): m/z = 161 [MH+] | [References]
[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 21, p. 6782 - 6795
[2] Patent: US2009/253679, 2009, A1. Location in patent: Page/Page column 37 |
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