| Identification | Back Directory | [Name]
2,2'-((3-(7-methoxy-4-methyl-2-oxo-2H-chromen-3-yl)propanoyl)azanediyl)diacetic acid | [CAS]
858770-07-7 | [Synonyms]
2,2'-((3-(7-methoxy-4-methyl-2-oxo-2H-chromen-3-yl)propanoyl)azanediyl)diacetic acid
Glycine, N-(carboxymethyl)-N-[3-(7-methoxy-4-methyl-2-oxo-2H-1-benzopyran-3-yl)-1-oxopropyl]- | [Molecular Formula]
C18H19NO8 | [MOL File]
858770-07-7.mol | [Molecular Weight]
377.35 |
| Chemical Properties | Back Directory | [Boiling point ]
683.0±55.0 °C(Predicted) | [density ]
1.393±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.95±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1]. | [References]
[1] Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. . |
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| Company Name: |
OTAVA chemicals
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| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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