| Identification | Back Directory | [Name]
7-[(2,6-dichlorophenyl)methoxy]-4-(2-oxochromen-3-yl)chromen-2-one | [CAS]
859142-95-3 | [Synonyms]
TDP1 Inhibitor-2
7-[(2,6-dichlorophenyl)methoxy]-4-(2-oxochromen-3-yl)chromen-2-one
[3,4'-Bi-2H-1-benzopyran]-2,2'-dione, 7'-[(2,6-dichlorophenyl)methoxy]- | [Molecular Formula]
C25H14Cl2O5 | [MOL File]
859142-95-3.mol | [Molecular Weight]
465.28 |
| Hazard Information | Back Directory | [Uses]
TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1]. | [References]
[1] Mamontova EM, et al. Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorg Med Chem. 2020 Jan 1;28(1):115234. DOI:10.1016/j.bmc.2019.115234 |
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PHARMEKS Ltd.
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